Bone Abstracts

Osteoporosis in premenopausal is dominated by secondary causes, among which anorexia nervosa, the female athletic triad, celiac disease, and glucocorticoid-induced osteoporosis (GIO) constitute the most frequent conditions. Stress fractures of the lower extremities and low energy fractures of the ribs, are also frequent. Various genetic causes like osteogenesis imperfecta tarda are probably underdiagnosed and various inflammatory conditions also play a role. A rare, but often ...

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Context: Previous impact microindentation studies have demonstrated that osteoporosis patients exhibit impaired bone material strength, which may contribute to skeletal fragility. Whether the impact differs between subtypes of fractures has, however, not been evaluated yet.Objective: To test whether impaired bone material properties differ between different subtypes of osteoporotic fracture and assess how this property relates to fracture severity.<p...

Bone marrow lesions (BMLs), previously denoted bone marrow edema are detected as water signals on MR scans (low intensity on T1 weighted images and high intensity on T2 weighted scans). Previous histologic studies were unable to demonstrate any edematous changes at the tissue level, which led us to hypothesize that the water signal stems from increased vascularization accompanying a high turnover state in bone. To test this hypothesis we performed tetracy...

Impaired bone material properties have been invoked as being responsible for the development of atypical femoral fractures (AFF) after long term bisphosphonate use. We therefore analyzed bone material properties in a bone biopsy obtained at the fracture site from an 88-year-old female with AFF, who had been treated with alendronate for 8 years. We used conventional histology, quantitative backscattered electron imaging (qBEI), and Raman spectroscopy (RS).<p class="abstext"...

Hip+ fracture rate in Norway is the highest registered in World, and more than double that of Spanish women. Previous studies were unable to demonstrate significant differences between the two populations with respect to bone mass or calcium metabolism. In order to test, whether the difference in fracture propensity between both populations could be explained by differences in bone material quality we assessed bone material strength using microindentation in 41 Norwegian and 4...

Hip fracture rate in Norway is the highest registered in World, and more than double that of Spanish women. Previous studies were unable to demonstrate significant differences between the two populations with respect to bone mass or calcium metabolism. In order to test, whether the difference in fracture propensity between both populations could be explained by differences in bone material quality we assessed bone material strength using microindentation in 41 Norwegian and 46...